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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
25.45
Human Site:
Y323
Identified Species:
46.67
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
Y323
E
E
E
E
L
K
P
Y
T
E
P
D
P
D
F
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
Y323
E
E
E
E
L
K
P
Y
T
E
P
D
P
D
F
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
E309
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
Dog
Lupus familis
XP_536123
782
87409
Y310
E
E
E
E
L
K
P
Y
A
E
P
E
P
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
Y323
E
E
E
E
L
K
P
Y
S
E
P
E
L
D
L
Rat
Rattus norvegicus
O08678
793
88216
Y323
E
E
E
E
L
K
P
Y
S
E
P
E
L
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
Y322
E
E
E
E
L
K
P
Y
L
E
P
E
P
D
F
Chicken
Gallus gallus
Q9IA88
798
88848
F291
R
Q
Q
Q
S
L
S
F
S
M
Q
N
Y
N
S
Frog
Xenopus laevis
NP_001085126
792
88624
Y323
D
E
E
E
L
K
P
Y
T
E
P
E
P
D
F
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
K330
I
V
E
C
E
Q
V
K
V
E
R
E
T
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
F433
E
D
D
E
L
K
P
F
I
E
P
P
K
D
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
R54
A
I
K
I
L
N
R
R
K
I
K
N
M
E
M
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
H175
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
100
0
86.6
N.A.
73.3
73.3
N.A.
86.6
0
86.6
13.3
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
100
100
20
93.3
N.A.
86.6
86.6
N.A.
93.3
46.6
100
33.3
N.A.
N.A.
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% A
% Cys:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
0
0
0
0
0
8
16
0
16
0
62
0
% D
% Glu:
54
54
62
62
8
0
0
8
0
70
8
47
0
24
0
% E
% Phe:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
39
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
8
0
0
8
8
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
8
0
8
0
0
8
8
0
0
0
0
0
% I
% Lys:
0
0
8
0
8
62
0
8
8
0
8
8
16
0
0
% K
% Leu:
0
0
0
0
70
8
0
0
8
0
8
8
16
0
24
% L
% Met:
0
0
8
0
0
0
0
0
0
8
0
0
8
0
8
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
16
0
8
8
% N
% Pro:
0
0
0
0
0
0
62
0
0
0
62
8
47
8
0
% P
% Gln:
0
8
8
8
0
8
0
0
0
0
8
0
0
0
8
% Q
% Arg:
16
0
8
0
0
0
8
8
8
0
8
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
8
0
24
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
24
0
0
0
8
0
0
% T
% Val:
0
8
0
0
8
0
16
0
8
0
0
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _